Combined Manganese-Enhanced MRI and DTI Methods to Assess Post-Myocardial Infarction Molecular and Structural Remodeling
نویسندگان
چکیده
B. Waghorn, W. Li, X. Yu, and T. C-C. Hu Department of Radiology, Medical College of Georgia, Augusta, Georgia, United States, Nuclear and Radiological Engineering and Medical Physics Programs, Georgia Institute of Technology, Atlanta, Georgia, United States, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, United States, Case Center for Imaging Research, Case Western Reserve University, Cleveland, Ohio, United States
منابع مشابه
Using Magnanese-Enhanced MRI to Monitor the Efficacy of Angiotensin Converting Enzyme Inhibitor Treatment in a Murine Myocardial Infarction
Introduction: The ischemically injured myocardium contains a mixture of viable and non-viable tissue post-myocardial infarction (MI); thus, a method to discern the various zones would be of great value in clinical management. The traditional approach in treatment attempts to salvage the viable peri-infarcted areas, by pharmaceutical intervention. A popular route of treatment is providing Angiot...
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Introduction: Manganese (Mn), a calcium analog, is an interesting contrast agent that enters excitable cells via L-type voltage dependant channels. Due to a strong T1 shortening effect when accumulating in tissue Mn can be used as an efficient marker of cell activity [1],[2]. In previous studies [3],[4] it has revealed a strong efficiency in the assessment of transmural fibrotic scar myocardial...
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Background Delayed Enhanced MRI (DEMRI) with gadolinium (Gd) is used as gold standard for diagnosis of myocardial infarction. However, the non-specific property of Gd overestimates the infarct size. Conversely, manganese (Mn2+) enters only the live, active cardiomyocytes via L-type Ca2+ channels. From our earlier work in animal MI models, manganese-enhanced MRI (MEMRI) has demonstrated its util...
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تاریخ انتشار 2009